Dupixent ( dupilumab ) is a mark - name injectant that ’s prescribe for treating asthma . This clause shroud subject such as side effects , dose , and how Dupixent works .
Dupixent is useable as a result inside individual - dose prefilled pens and syringes , given as asubcutaneous injectant . Dupixent is abiologicand belongs to a drug social class called interleukin-4 ( IL-4 ) sensory receptor blockers . The medicine is not available in a biosimilar version .
study on for more info about Dupixent . you may also bear on to this other clause for a comprehensive smell atDupixentand its other uses .
Asthma explained
Dupixent is approved to treat certain types ofasthma . With asthma , inflammation ( excrescence ) and mucus in the lining of your airways make it hard to breathe .
Specifically , Dupixent is approve to cover restrained to severe asthma attack that is either :
For these use , Dupixent is typically dictate as an tot - on maintenance treatment . This means you ’ll in all probability take Dupixent with other medications that treat bronchial asthma , such as inhaled budesonide ( Pulmicort ) .
Dupixent should never be used to treat anasthma flak . It does not work promptly enough to regale parking brake symptoms . Always apply your rescue inhaler as instructed by your Dr. to treat symptom of asthma attack attack .
Symptoms of asthma
Symptoms of asthma attack include :
Who Dupixent is prescribed for
Dupixent is prescribed to care for moderate to severe asthma attack in adults and children ages 6 years and older .
How Dupixent treats asthma
Dupixent is prescribe to treat asthma that is restrained to severe and meets either of the following criterion :
For these uses , Dupixent is meant as an append - on treatment . This means Dupixent is used together with other medications that deal asthma . Below is selective information on how Dupixent work to treat asthma . How a medicament kit and boodle is also call in its chemical mechanism of action .
Note : Dupixent should not be used to treat an bronchial asthma attack . The medication does n’t work quickly enough to treat parking brake symptoms . Always utilise your rescue inhaler as instructed by your medico to treat asthma attack attack symptoms .
The way Dupixent works
Dupixent works by blocking signaling send by interleukin-4 ( IL-4 ) and interleukin-13 ( IL-13 ) . interleukin , include IL-4 and IL-13 , are a eccentric of protein which send signals that trigger off a reception from your immune system .
In reaction to signaling by IL-4 and IL-13 , your immune system creates inflammation . This inflammation is helpful for keeping you healthy by fighting infection . But in the absence of infection , this excitement can be harmful . With bronchial asthma , it make your airways to become fire up and obturate by fluid and mucous secretion , ca-ca it difficult to breathe .
By blocking IL-4 and IL-13 signaling , Dupixent mold to minify inflammation in your airways . This loosen your airway and makes it easier to pass off .
Dupixent and children
Dupixent is prescribed to children ages 6 years and older for process treat temperate to spartan asthma that ’s either eosinophilic or dependent on unwritten corticoid . For this purpose , it ’s approved as an add - on treatment used with othertreatments for eosinophilic asthma .
How well Dupixent works
You may be curious about how well Dupixent works for asthma if your MD prescribes this medication to you .
Clinicalstudiesfound Dupixent effective for treating eosinophilic or oral corticosteroid - dependent asthma in grownup and certain children .
In these studies , people continued taking their current asthma attack medications . Some also received Dupixent , while others receive a placebo ( shot with no active drug ) . In these written report , hoi polloi care for with Dupixent and their other asthma medications know few asthma aggravation compared to the great unwashed who experience a placebo in addition to their usual asthma medications .
To learn more about Dupixent ’s success rate for asthma in these survey , moderate out the medicament ’s prescribing information .
Dupixent and several other biologic medicament approved as add - on medications for treating asthma are recognized as discussion options by theAsthma and Allergy Foundation of America ( AAFA ) . “ Add on ” means they ’re typically used together with other medication for treating bronchial asthma .
In summation to how well it mold , you may also need to bonk how long it takes Dupixent to help asthma attack . In studies , some people noted a reduction in symptoms as presently as 2 hebdomad after starting discourse . But it can take several weeks or months before Dupixent ’s full effects take hold .
verbalize with your doctor or pharmacist if you ’d like to take more about how well Dupixent works for treating asthma .
Using Dupixent
Dupixent fall as a liquidness inside single - dose , prefilled pens or syringes , to be given as asubcutaneous injection .
Dosage
Dupixent dosages for eosinophilic and unwritten corticosteroid - drug-addicted bronchial asthma vary based on age . In minor , dosage also vary based on body weight .
If the medicinal drug works well for you , you ’ll in all probability stay on Dupixent for bronchial asthma long condition . Your exact intervention distance will depend on decisions made by you and your doctor .
For regale asthma in adults , you ’ll first receive a loading dose . This is a larger dose think of to get enough Dupixent into your scheme quickly so it can begin run . Your loading dose will be either 400 milligrams ( mg ) ( consisting of two 200 - mg injection ) or 600 mg ( consist of two 300 - mg injections ) .
Then , you ’ll find a dose of either 200 atomic number 12 ( if you received a 400 - mg loading STD ) or 300 mg ( if you receive a 600 - mg load dose ) every 2 workweek . This is scream your maintenance STD .
Dupixent is also prescribe for asthma in children eld 6 days and older . For baby 12 years and old , dosage are the same as described in adults above .
For children ages 6 to 11 year , Dupixent STD for asthma depend on the fry ’s dead body weight in kilograms ( kg ) . One kg be about 2.2 pounds ( lb ) .
For more information on Dupixent dosages for asthma , you’re able to view ourDupixent dosage articleor Dupixent’sprescribing information .
mark : In addition to treating bronchial asthma , Dupixent has other uses . Keep in nous that the drug ’s dosage may dissent with these other use of goods and services . To determine more , talk with your doctor .
How to use
Dupixent come as a liquidness inside single - dose , prefilled pen or syrinx , to be given as a subcutaneous injectant . Your MD or pill roller will show you how to give yourself ( or your minor ) injections at home when you ’re first dictate Dupixent .
you’re able to give your Dupixent injections into your thigh or stomach . For your tum , take a site that ’s at least 2 column inch away from your belly clit . If you ’re giving Dupixent injections to your tiddler , or someone else is give your Dupixent dose , Dupixent Venus’s curse can also be put in into the outer surface area of the upper arm . You should rotate between dissimilar injection internet site with each dose of Dupixent . This helps keep shot - site response , such as pain or irritation .
Children get on 12 year and above may give themselves Dupixent injections under close supervising by a parent or guardian . small fry under age 12 should receive doses from a parent , primary care provider , or healthcare professional .
Before inject Dupixent , take it out of the refrigerator and allow for it to progress to elbow room temperature . This will take about 45 minute for the 2 - mil ( mL ) pens or syringes , and about 30 minutes for the 1.14 - mL pens or syringes .
For whole tone - by - step instructions on interpose Dupixent , you’re able to view grooming telecasting onDupixent ’s producer site . There are also injection instructions in Dupixent’sprescribing information . you could also ask your pharmacist or doctor if you need help inject Dupixent .
How often to use
For treating asthma in adults , you ’ll first obtain one burden dose that consists of two injections . Then , you ’ll take Dupixent once every 2 hebdomad .
How often baby invite Dupixent for asthma attack depends on the small fry ’s body weightiness in kg . After pick up a loading dose :
Talk with your or your tiddler ’s doctor if you have other questions about how often to take Dupixent for bronchial asthma .
Dupixent side effects
The utilisation of Dupixent for asthma attack * may cause side effects that are mild or serious . The inclination below let in some of the main side outcome that have been reported with Dupixent .
For entropy about other likely side effects of the drug , talk with your doctor or pharmacist . you could also see ourside core clause about Dupixentor refer to Dupixent’sprescribing entropy .
take down : After the Food and Drug Administration ( FDA ) approves a medicine , it tracks and brush up side effects of the drug . If you build up a side burden while using Dupixent and would like to inform the FDA , visitMedWatch .
- Dupixent is also approved to treat other conditions . It ’s important to remark that side effects from Dupixent may take issue calculate on the condition it ’s being used to treat .
Mild side effects
Mild side effectsreportedwhen Duxipent is used to treat asthma include :
These side gist of Dupixent may be temporary , lasting a few 24-hour interval to weeks . But if they last longer than this , or if they trouble oneself you or become knockout , it ’s important to talk with your doctor or pharmacist .
Serious side effects
While rare , serious side effects are potential with Dupixent treatment . Serious side effectsreportedwith Dupixent let in :
- While eosinophilic conditions have been reported in mass using Dupixent for bronchial asthma , it ’s not make out for certain whether Dupixent or another factor caused these side effects .
Call your doctor right aside if you develop serious side effects while using Dupixent . If the side effects seem life threatening or you think you ’re have a aesculapian pinch , call 911 or your local emergency number now .
For some the great unwashed , Dupixent can cause anallergic reaction .
In general , symptom of hypersensitized reaction can be mild or serious .
elbow room to manage
For balmy supersensitised reaction symptoms , such as a mild rash , call your doctor correctly aside . They may recommend treatments to help oneself manage your symptoms . They ’ll also permit you know whether you should keep taking the medication .
For severe allergic chemical reaction symptoms , such as excrescence or trouble breathing , call 911 or your local emergency routine in good order away . These symptoms require immediate aesculapian forethought because they can become life threatening . If you ’ve had a serious sensitised reaction to Dupixent , your doctor may recommend occupy a different medicament instead .
Before using Dupixent
Before you utilise Dupixent , there ’s some important data to keep in mind . The drug may not be a good selection if you have certain medical condition or other factors that affect your health . Some of these are mentioned below .
Warnings
If any of the follow medical conditions or other wellness factors are relevant to you , talk with your doctor before using Dupixent :
Dupixent cost
How much Dupixent monetary value is found on several broker . These can include your prescribed treatment regimen , your policy architectural plan , the chemist’s you practice , and your location .
Dupixent is abrand - namebiologicdrug . It ’s not available in a biosimilar translation . biological medications are made using living cells . As a result , it ’s not potential to make an exact copy of them . A biosimilar is a medicinal drug based on the brand - name biologic drug , sometimes called the parent drug . Biosimilars are consider to be as good and effective as their brand - name parent drug .
Disclaimer : Medical News Today has made every effort to make sealed that all information is factually right , comprehensive , and up to date . However , this article should not be used as a substitute for the knowledge and expertness of a commissioned healthcare professional . You should always confab your doctor or another health care professional before lead any medication . The drug information contained herein is subject to change and is not destine to cover all potential manipulation , focal point , precautions , warnings , drug interaction , allergic reactions , or adverse effect . The absence seizure of admonition or other information for a give drug does not argue that the drug or drug combining is safe , effective , or appropriate for all patient or all specific utilization .
