Koselugo is a brand name - name oral abridgment prescribed to treat a type of nerve tumor in sure children . Koselugo contains the participating element selumetinib and belongs to the kinase inhibitor drug course .
Specifically , the Food and Drug Administration ( FDA ) has approved Koselugo to treatneurofibromatosis character 1 - relate plexiform neurofibromas ( NF1 - PN)in sure children old age 2 years and old . With NF1 - PN , noncancerous tumorsgrow on nerves outside the brain and spinal cord .
Drug details
You ’ll find central information about Koselugo here :
Koselugo generic
Koselugo is available only as a brand - name medicine . It ’s not presently useable ingeneric anatomy .
A generic drug is an precise copy of the combat-ready ingredient in a sword - name medicament . Generics usually cost less than brand - name drug .
Koselugo price and coupons
As with all medications , the toll of Koselugo can diverge . The actual monetary value you ’ll make up depends on your child’sinsuranceplan , your position , and the chemist’s you use .
Drug coupons : you’re able to claver Optum Perks for price estimates ofKoselugo . These estimates are based on the utilization of Optum Perks voucher . Note : Optum Perks voucher can not be used with insurancecopaysor benefits .
fiscal and insurance assistance : If you need financial support to pay for Koselugo or need assistance understand your child ’s insurance coverage , help oneself is available .
A plan calledOneSource CoPay Programis useable for Koselugo . call in the programme internet site for more information and to witness out if your child is eligible forsupport .
Koselugo side effects
Koselugo can cause mild or serious side effects . The following lists contain some of the fundamental side event that may occur while taking Koselugo . These lean do not include all possible side issue .
For more information about the possible side impression of Koselugo , verbalise with your child ’s doctor or pharmacist . They can give you tips on how to manage any side burden that may be concerning or irritating .
Note : After the Food and Drug Administration ( FDA ) approves a drug , it tracks and reviews side burden of the medicine . portion out your nipper ’s experience help make medications safe for everyone by giving Doctor of the Church and investigator more info about how the drug put to work in substantial life . If your child develop a side effect while taking Koselugo and you want to tell the FDA about it , visitMedWatchor call 800 - FDA-1088 .
Mild side effects
Here is a partial list of meek side upshot of Koselugo . To learn about other mild side gist , spill the beans with your nipper ’s doctor or pharmacist or view Koselugo’sprescribing information .
modest side effects of Koselugo can let in :
Most of these side outcome may go away within a few days to a duet of weeks . However , if they become more severe or do n’t go away , talk with your child ’s MD or pharmacist .
Serious side effects
Serious side effects from Koselugo are n’t common , but they can occur . Call your nestling ’s doctor right off if your minor has serious side effects . Call 911 or your local emergency phone number if your kid ’s symptoms seem life threatening or you call up they ’re have a medical emergency .
Serious side effect can include :
For some mass , Koselugo can have anallergic response . But this side effect was n’t reported in the drug’sclinical trial .
In general , symptoms of an allergic chemical reaction can be mild or serious .
Ways to wield
For balmy allergic chemical reaction symptom , such as a mild rash , call your tyke ’s doctor right aside . They may recommend treatment to facilitate oversee your child ’s symptom . They ’ll also let you sleep together whether your nipper should keep taking the medication .
For severe hypersensitized reaction symptom , such as swelling or trouble external respiration , call 911 or your local emergency number justly forth . These symptoms involve straightaway medical precaution because they can become liveliness threatening . If your shaver has a serious hypersensitive response to Koselugo , their MD may recommend a dissimilar medication instead .
Koselugo uses
The Food and Drug Administration ( FDA ) approve prescription drugs such as Koselugo to treat certain conditions .
Koselugo for NF1-PN
Koselugo is okay to treatneurofibromatosis type 1 - associated plexiform neurofibromas ( NF1 - PN)in youngster ages 2 years and older . Koselugo is not presently approved for enjoyment in adult .
Neurofibromatosis is a rareinherited conditionthat increases the risk of tumour growth . With NF1 - PN , noncancerous tumorsdevelop on the peripheral nerve ( the nerves outside the brain and spinal cord ) . Symptoms may include hurting and difficulty listening , breathing , or moving .
Koselugo is order when neoplasm are causing symptoms but can not be dispatch with OR .
To discover more about Koselugo for NF1 - PN , talk with your child ’s doctor .
Koselugo dosing
The Koselugo dose your tike ’s Doctor of the Church prescribes will calculate on several factors . These admit :
The following entropy describes dosages that are commonly used or recommended . However , be sure your child consider the dose their doctor prescribes . The doctor will determine the good dose to fit your child ’s needs .
Drug form and strengths
Koselugo comes as an unwritten ejection seat in two strengths : 10 milligram ( mg ) and 25 mg .
Dosage for NF1-PN
Koselugo is used to treatneurofibromatosis case 1 - associated plexiform neurofibromas ( NF1 - PN)in certain fry eld 2 years and older . To learn more about this use , see the “ Koselugo use ” subdivision .
The recommend dosage is 25 mg / m² twice per daytime ( “ mg / m² ” refers to milligrams per time square , which is based on your child ’s height and weight ) .
Your child ’s doctor will reckon the proper dose based on your baby ’s height and weight .
How to take
Your child should unsay Koselugo oral capsule whole with water . The capsule should not be chewed , dissolved , or opened .
About taking Koselugo
You ’ll find data about key dose issue here :
Overdose
Your child should not take more Koselugo than their doctor recommends . For some drug , doing so may lead to unwanted side effects or overdose .
If you imagine your child has taken too much of this drug , call your child ’s Dr. . you’re able to also call America ’s Poison Centers at 800 - 222 - 1222 or use itsonline cock . However , if your tike ’s symptoms are spartan , call 911 or your local emergency figure or go to the nearest emergency way right away .
Koselugo interactions
Koselugo caninteractwith several other medications . It can also interact with certainvitamins .
Before your child takes Koselugo , talk with their doctor and pharmacist . separate them about all prescription , over - the - counter , and other drug your child takes . Also tell them about any vitamin , herbs , andsupplementsyour child takes . Sharing this entropy can help your child invalidate likely fundamental interaction .
Interactions with medications, foods, and supplements
Here is a list of heart that can interact with Koselugo . This leaning does not moderate all drugs that may interact with Koselugo . If you have questions about drug fundamental interaction that may affect your child , call for their doctor or pharmacist .
Alcohol interaction
intoxicant is not known to interact with Koselugo . If you have interrogation about alcohol and Koselugo , talk with your child ’s doctor or pharmacist .
Similar drugs
Other drugs are available that can regale your child ’s condition . Some , such asGomekli(mirdametinib ) , may be a practiced primed for your tyke than others .
If you ’re interested in finding an option to Koselugo , talk with your child ’s doc . They can recite you about other medications that may work well for your child .
Things to consider when taking Koselugo
look at the following information about pregnancy , birth control , and breastfeeding .
Koselugo and pregnancy
Koselugo should not be conduct during pregnancy . Based onanimal study , Koselugo can cause fetal harm . If your child can become pregnant , verbalize with their medico before they set about Koselugo discourse . Their Doctor of the Church may propose nascence control choice to expend during treatment .
Koselugo and birth control
Koselugo should not be taken during gestation . If your child is sexually active and they or their partner can become pregnant , blab out with their doctor about theirbirth controloptions during Koselugo treatment . Specifically :
observe : Sex and genderexist on spectrum . Use of the footing “ female ” and “ male person ” in this article refers to sex attribute at giving birth .
Koselugo and breastfeeding
hoi polloi should not suckle during Koselugo intervention and for at least 1 calendar week after their final dose . If your child is presently breastfeed or planning to do so , verbalize with their physician before they start Koselugo discourse . Your child ’s Dr. may intimate a different treatment for their status or recommend other ways to feed a child who is breastfed .
Common questions about Koselugo
Here are answers to some frequently asked questions about Koselugo .
Is Koselugo chemotherapy?
No , Koselugo is considered atargeted therapyrather thanchemotherapy .
direct therapies are made to specifically attacktumorcells . Chemotherapy target apace growing cell , which include both tumor cells and goodish cells that usually grow speedily . These cells include those in your whisker follicle and digestive parcel of land . Because of this , chemotherapy tends to have more side effects .
Targeted therapy such as Koselugo also have side effects , but they may not be as grievous as some side effects of chemotherapy or may not happen as often . Mild and serious side effect are still potential with Koselugo . For contingent about the side effects of Koselugo , see the “ Koselugo side effects ” department .
If you have doubtfulness about Koselugo and chemotherapy , babble out with your child ’s doctor .
How does Koselugo work?
Koselugo belong to a drug class called kinase inhibitors . It works by blocking specific proteins called mitogen - activated protein kinase kinases 1 and 2 ( MEK1/2 ) in tumor cells .
cellphone with spark off MEK1/2 protein can grow uncontrollably , causing tumors to develop . This is what materialize inneurofibromatosis type 1 - associated plexiform neurofibromas ( NF1 - PN ) , the tumor type that Koselugo is approved to treat . ( To learn more , see the “ Koselugo use ” section . )
By bar MEK1/2 , Koselugo can concentrate the growth of NF1 - PN , which can help excuse the symptoms of the tumor .
If you have questions about how Koselugo works , talk with your nipper ’s physician .
Koselugo precautions
Before learn Koselugo , talk about your nipper ’s health history with their doctor . Koselugo may not be right for your child if they have sure medical conditions or other factor affect their health . Be certain to talk with your child ’s Dr. if any of the following apply to your child :
Note : For more entropy about the likely damaging burden of Koselugo , see the “ Koselugo side upshot ” section .
Disclaimer : Medical News Today has made every effort to make certain that all information is factually correct , comprehensive , and up to date . However , this article should not be used as a substitute for the noesis and expertise of a commissioned health care professional . You should always consult your fry ’s doc or another health care professional before taking any medication . The drug information contained herein is capable to alteration and is not destine to cover all potential utilisation , direction , precautions , monition , drug interactions , supersensitive reactions , or adverse effects . The absence of warnings or other information for a give drug does not betoken that the drug or drug combining is safe , effective , or appropriate for all patients or all specific United States .
