Livdelzi is a brand - name oral capsule prescribed for a liver circumstance called master bilious cholangitis ( PBC ) . Livdelzi contains the active ingredient seladelpar .
The Food and Drug Administration ( FDA ) has approved Livdelzi to regale a rare liver condition calledPBCin adults . Livdelzi is used in combination with a medication called ursodeoxycholic acid ( UDCA ) or on its own in people who ca n’t take UDCA . For details , see “ Livdelzi for principal biliary cholangitis . ”
Drug details
You ’ll find key info about Livdelzi here :
take down : Livdelzi is a novel medication for PBC . The FDA gives speed up approval to sure drugs if early clinical test suggest that they may be effectual for treat a certain shape . More extensive clinical visitation must then be done to affirm whether the drug provides actual benefit for hoi polloi with that condition . Based on the results of these study , the FDA may decide to fully approve the drug or withdraw the approval .
Livdelzi generic
Livdelzi is useable only as a firebrand - name medication . It ’s not presently available ingeneric cast .
A generic drug is an exact transcript of the active ingredient in a make - name medication . Generics usually cost less than stigma - name drugs .
Livdelzi dosage
The following selective information describes dosages that are usually used or recommended . However , be sure to take the dose your doctor prescribe for you . Your doctor will determine the respectable dosage to fit your need .
Drug forms and strengths
Livdelzi comes as an oral condensation in one strength : 10 milligrams ( mg ) .
Dosage for primary biliary cholangitis (PBC)
The advocate dose for PBC is 10 mg , read once per day .
About taking Livdelzi
You ’ll find selective information about key dosage return here :
Overdose
Taking more than the recommended dosage of Livdelzi can lead to serious side effects . Do not take more Livdelzi than your doctor commend .
Symptoms of a Livdelzi overdose can let in :
If you think you ’ve train too much of this drug , call your doctor . you may also call America ’s Poison Centers at 800 - 222 - 1222 or habituate itsonline dick . However , if your symptom are severe , call 911 or your local emergency number or go to the nearest emergency room properly forth .
Livdelzi side effects
Livdelzi can cause mild or serious side effects . The following lists hold in some of the key side essence that may occur while taking Livdelzi . These lists do not include all potential side effects .
For more information about the potential side effect of Livdelzi , sing with your doctor or pill pusher . They can give you top on how to wield any side effects that may be worry or plaguey .
Note : After the Food and Drug Administration ( FDA ) approve a drug , it tracks and review side effect of the medication . share your experience help make medicament safer for everyone by giving doctor and researchers more information about how the drug works in real life . If you develop a side upshot while direct Livdelzi and want to recount the FDA about it , visitMedWatchor call 800 - FDA-1088 .
Mild side effects
Here is a fond list of mild side consequence of Livdelzi . To see about other balmy side effects , talk with your doc or druggist , or consider the drug’sprescribing info .
soft side effects of Livdelzi can admit :
Most of these side effects may go aside within a few day to a couple of week . However , if they become more dangerous or do n’t go away , tattle with your MD or pill pusher .
Serious side effects
Serious side effects from Livdelzi are n’t vernacular , but they can pass . Call your doctor right on away if you have serious side effects . Call 911 or your local emergency brake phone bit if your symptom feel life threatening or you think you ’re bear a aesculapian emergency .
Serious side effects and their symptoms can include :
For some people , Livdelzi can do anallergic response , but it ’s not clear whether this side effect occurred in the drug’sstudies .
In general , symptoms of an hypersensitive reaction can be mild or serious .
Ways to manage
For mild allergic reaction symptoms , such as a modest blizzard , call your doctor right aside . They may recommend treatments to help handle your symptoms . They ’ll also lease you jazz whether you should keep taking the medication .
For severe allergic response symptom , such as hump or trouble breathing , call 911 or your local exigency identification number decently away . These symptoms require immediate aesculapian care because they can become living jeopardise . If you ’ve had a serious supersensitised reaction to Livdelzi , your Doctor of the Church may recommend a dissimilar medication instead .
Livdelzi for primary biliary cholangitis
The Food and Drug Administration ( FDA ) approves prescription drugs such as Livdelzi to treat sure conditions .
Livdelzi for primary biliary cholangitis (PBC)
Livdelzi is approved to treatPBCin adults in certain situations . ( Cholangitis meansinflammationof the bile ducts . ) PBC is a rarefied autoimmune disease that bear upon thebile ductsin your liver and causesliver impairment .
With PBC , your immune scheme erroneously attacks and damages your gall ducts . This causesbile(a liquid kernel your liver makes ) to build up in your liver , which leads to ongoing liver damage . PBC can eventually causecirrhosis(scarring ) and evenliver failure .
PBC may not induce symptoms until liver damage has happened . If symptom do happen , they can includefatigue , itching , and abdominal pain in the neck in your upper correct side .
PBC also have elevated floor of a liver enzyme calledalkaline phosphatase ( ALP ) . When cells in your liver are damaged , they release ALP into your blood . Doctorsdiagnose PBCwith a blood test that measure out the storey of this and other liver enzyme . However , since PBC does n’t typically cause symptom , it ’s unremarkably diagnosed after a routine blood tryout done for a different reason .
Livdelzi intervention reduces ALP level and eases symptoms of PBC . Livdelzi is approve for use in combining with ursodeoxycholic acid ( UDCA ) in people whose PBC symptoms are not well managed with UDCA . Livdelzi is also okay to treat PBC on its own in mass who can not take UDCA due to its side effect .
Livdelzi and children
Livdelzi is not approved for use in children . The manufacturer has not studied Livdelzi in the great unwashed under 18 year quondam .
Livdelzi interactions
Livdelzi caninteractwith several other medications .
Before taking Livdelzi , talk with your doctor and pharmacist . separate them about all ethical drug , over - the - buffet , and other drug you take . Also tell them about anyvitamins , herbs , and supplements you use . Sharing this information can help oneself you avoid potential interactions .
Interactions with medications
Here is a listing of medications that can interact with Livdelzi . These medications may dissemble the storey of Livdelzi in your body , which may bear upon how the drug works or increase the risk of side effects . This inclination does not contain all drugs that may interact with Livdelzi . If you have questions about drug interactions that may affect you , ask your doctor or pharmacist .
Alcohol interaction
alcoholic beverage is not known to interact with Livdelzi . However , your doctor may counsel you to limit the amount of alcohol you consume . This is because grueling or longsighted - termalcohol consumptionand master biliary cholangitis ( PBC ) can both damage the liver . Livdelzi serve cover PBC , so drinking intoxicant may reduce how effective Livdelzi is in treating your condition .
If you have question about how much alcohol is safe to booze while taking Livdelzi , talk with your Dr. or pharmacist .
Livdelzi cost
As with all medications , the cost of Livdelzi can motley . The actual price you ’ll compensate depends on yourinsuranceplan , your location , and the chemist’s you use .
Financial and insurance assistance : If you postulate fiscal support to yield for Livdelzi or help understand your insurance coverage , help is available .
A syllabus ring Gilead Support Path is available for Livdelzi . For more entropy and to find out if you ’re eligible for support , call 855 - 769 - 7284 or call theprogram web site .
Similar drugs
Other drugs are available that can treat your condition . Some may be a better fit for you than others . If you ’re concerned in rule an alternative to Livdelzi , verbalise with your medico . They can assure you about other medications that may work well for you .
The only medication that ’s exchangeable to Livdelzi is elafibranor ( Iqirvo ) .
Things to consider when taking Livdelzi
If you could become pregnant , conceive the following data about pregnancy , fertility , giving birth ascendance , and breastfeeding .
Livdelzi and pregnancy
It ’s not bed whether Livdelzi should be taken during pregnancy . There have not been enoughstudiesin humans to determine whether there ’s a jeopardy to the fetus if Livdelzi is taken during pregnancy . If you ’re design a pregnancy or can become pregnant , utter with your doctor before bring this medicament .
If you and your doctor decide on Livdelzi discussion during gestation or you become pregnant during treatment with Livdelzi , consider report the maternity to the drug ’s manufacturer ( Gilead ) by calling 800 - 445 - 3235 .
Livdelzi and birth control
It ’s not known whether Livdelzi is dependable to take during maternity . If you ’re sexually active and you or your cooperator can become meaning , utter with your MD about yourbirth controloptions while you ’re taking Livdelzi .
Livdelzi and breastfeeding
It ’s not known whether Livdelzi should be taken while breastfeeding . If you ’re currently breastfeeding or planning to do so , talk with your doctor before taking this medication .
How Livdelzi works
The way a drug works is bonk as its mechanics of action . The exact way Livdelzi go to treatprimary bilious cholangitis ( PBC)is not completely understood .
Livdelzi belongs to a class of drug prognosticate peroxisome proliferator - activated receptor ( PPAR)-delta agonist . Medications in this drug class bring down how muchbilethe liver defecate .
With PBC , gall builds up in the liver and damages it . It ’s reckon that Livdelzi slows PBC liver wrong by decreasing gall production and buildup .
Inclinical study , Livdelzi led to reduced grade ofalkaline phosphatase ( ALP ) , a liver enzyme that ’s released from damaged liver cells in people with PBC . To learn more about this stipulation , see the “ Livdelzi for primary bilious cholangitis ” section .
If you ’d like more information about Livdelzi ’s mechanism of action at law , talk with your MD or pharmacist .
Livdelzi precautions
Before carry Livdelzi , discourse your health chronicle with your doctor . Livdelzi may not be right for you if you have certain medical conditions or other factors affecting your wellness . Be sure to talk with your doctor if any of the following hold to you :
Note : For more information about the potential minus effects of Livdelzi , see the “ Livdelzi side effects ” division .
Disclaimer : Medical News Today has made every effort to make certain that all information is factually correct , comprehensive , and up to date . However , this article should not be used as a substitute for the noesis and expertness of a licenced health care professional . You should always look up your doctor or another health care professional before taking any medication . The drug information contained herein is dependent to modification and is not destine to cut across all possible use , directions , precaution , warnings , drug interaction , hypersensitized reactions , or adverse effects . The absence of warning or other information for a given drug does not designate that the drug or drug combination is good , effective , or appropriate for all patients or all specific use .
