Nucala ( mepolizumab ) and Dupixent ( dupilumab ) are brand name - name subcutaneous injection . They ’re both prescribe for asthma and chronic rhinosinusitis with nasal polyps . Each drug may also be prescribed for other uses .
This clause explains the main similarities and differences between Nucala and Dupixent . If you ’re considering treatment with one of these drug , discussing this information with your doctor can assist you make up one’s mind if one of these drugs may be right for you .
Note : For more comprehensive information about these two drugs , you may touch to ourNucalaandDupixentarticles .
Key differences between Nucala and Dupixent
These are a few of the chief difference of opinion between Nucala and Dupixent :
Generics or biosimilars: Nucala and Dupixent
Here ’s information about thebiosimilarstatus for Nucala and Dupixent , as well as detail on their combat-ready constituent . ( Biosimilars are likegenericversions of biologic drugs . )
Uses of Nucala vs. Dupixent
Nucala and Dupixent have been approved by the Food and Drug Administration ( FDA ) to treat the following shape in certain situations .
Nucala or Dupixent and children
Nucala and Dupixent are FDA approved to handle sure shape in children .
Specifically , both Nucala and Dupixent are sanction to treat eosinophilic asthma in children age 6 twelvemonth and old . Nucala is also okay to treat HES in children ages 12 class and older .
In addition , Dupixent is approved to treat the chase :
Note : For more information about the drug ’ uses , see our articles aboutNucalaandDupixent . you may also take in these article aboutDupixent for asthmaandDupixent for EoE.
Dosages, forms, and administration
Here ’s a immediate look at the dose and administration of Nucala and Dupixent for the stipulation both drugs treat .
Dosage for eosinophilic asthma in adults
Below are the dose of Nucala and Dupixent for treating eosinophilic bronchial asthma in adults . Strengths of each drug are list in milligrams ( mg ) and mg per milliliter ( mL ) .
Your doctor will show you or a health care provider how to shoot Nucala or Dupixent at home , or you may go to their power for shot .
You ’ll receive Nucala or Dupixent as an injection under the skin of your belly or thigh . Your MD or a caregiver can also inject either drug under the skin of your upper weapon .
you may view instructions on the manufacturer ’s website forNucalaorDupixent .
Dosage for chronic rhinosinusitis with nasal polyps (CRwNP) in adults
Below are the dosages of Nucala and Dupixent for treat CRwNP in adults . Strengths of each drug are listed in mg and mg per mL.
Children’s dosage
Below are inside information about the dosage of Nucala and Dupixent for the consideration both drugs regale in child .
Below are the dosages of Nucala and Dupixent for deal eosinophilic asthma in child age 6 years and older . intensity level of each drug are name in mg and mg per mL.
sure dosages are based on a nipper ’s age or weight in kilograms ( kg ) . For reference , 1 kg is about 2.2 Irish pound ( lb ) .
Your minor ’s Dr. will show you or your child how to inject Nucala or Dupixent at home . Your child may also go to their MD ’s office for injections . Nucala and Dupixent can be given as an injectant under the skin of your child ’s belly , second joint , or upper weapon system .
Note : For more selective information about dosage , see our dosage article aboutNucalaandDupixent .
Side effects of Nucala vs. Dupixent
Both Nucala and Dupixent are monoclonal antibody that treat standardized conditions . These drug can cause some of the same side effects , as well as some different ones . Some of the side effects describe in clinical trials of these drugs are mentioned below .
For more details about side effect of the two drugs , see our side consequence articles aboutNucalaandDupixent . you could also refer to theNucala prescribing informationandDupixent prescribing information .
Mild side effects
The following table lists some of the more commonly report mild side event of Nucala and Dupixent . The tabular array may also admit mild side effects that are less vernacular but that you might have worry about in some type .
These side core may be temporary , live a few days to weeks . If the side effect last longer than that , bother you , or become severe , be certain to spill with your doctor or druggist .
Serious side effects
The following table lists the reported serious side effects of Nucala and Dupixent .
If you have serious side gist while using Nucala or Dupixent , call your Doctor of the Church immediately . If the side event experience life threatening or you believe you ’re give a aesculapian emergency , call 911 or your local emergency number right off .
For some people , Nucala or Dupixent can cause anallergic response .
In general , symptoms of supersensitive chemical reaction can be modest or serious .
Ways to manage
For balmy allergic chemical reaction symptom , such as a mild blizzard , call your MD right off . They may commend treatments to assist manage your symptom . They ’ll also rent you know whether you should keep taking the medication .
For terrible supersensitized reaction symptoms , such as intumescence or difficulty ventilation , call 911 or your local emergency number right away . These symptoms require immediate aesculapian attention because they can become life threatening . If you ’ve had a serious allergic response to Nucala or Dupixent , your doctor may recommend a different medicinal drug rather .
Frequently asked questions
Below are answers to some common query about Nucala and Dupixent .
How do Nucala and Dupixent compare with similar drugs, such as Fasenra and Xolair?
Nucala , Dupixent , Fasenra , andXolairaremonoclonal antibodydrugs . They ’re allsubcutaneous injectionsapproved to handle sure types of asthma . Each drug has other use as well .
Below are a few way these medications equate .
If you have other questions about how these drugs equate , talk with your doctor or apothecary . They can separate you about other factors , such as cost , that may dissemble which treatment is right for your condition .
Can I use Nucala and Dupixent together?
The possibility of using Nucala and Dupixent together depends on your condition and your doctor ’s testimonial .
Both Nucala and Dupixent are used to treat eosinophilic bronchial asthma and CRwNP . The two drug work in dissimilar ways to reduce inflammation related to these conditions .
Some reports suggest that using these drugs together may help with difficult - to - manage symptoms of asthma attack , CRwNP , and other condition . However , the safe and effectiveness of this compounding is still being studied .
If you have questions about using Nucala and Dupixent together , talk with your doc . They can determine whether this combination is dependable and appropriate for your specific consideration .
Effectiveness of Nucala vs. Dupixent
Keep reading for details about the effectiveness of Nucala and Dupixent .
Review of studies : Areview of studiesfound that both Nucala and Dupixent are in force for managing symptom of eosinophilic asthma . A separatereview of studiesfound that Dupixent may be more in force than Nucala for managing symptom of continuing rhinosinusitis with adenoidal polyps ( CRwNP ) .
However , the consequence of research studies may not apply to your specific health situation . Your doctor can determine whether Nucala or Dupixent may be correct for you .
Prescribing selective information : For details about how these drug perform in clinical trials , see the prescribing information forNucalaandDupixent . Keep in mind that test effect may not apply to your private wellness situation .
Treatment guidelines : Another way to see whether a drug is considered good is to look at discourse guidepost . When an organization includes sealed drug in discussion guidelines , this mean that research has depict the drug to be safe and effective .
Nucala and Dupixent are commend as treatment options for asthma attack in guideline from theGlobal Initiative for Asthma . Both drug are also listed as treatment options for CRwNP in steering from theAmerican Academy of Otolaryngology – Head and Neck Surgery .
Cost of Nucala vs. Dupixent
How muchNucala costsorDupixent costsdepends on the intervention plan your doctor prescribes , your insurance program , and your pharmacy .
Both Nucala and Dupixent are brand - name drug . Neither drug is uncommitted in abiosimilarform . ( Biosimilars are likegenericversions of biological drug . ) mark - name medications are often more expensive than biologics .
Precautions for Nucala and Dupixent
Nucala and Dupixent may not be correct for you if you have certain aesculapian conditions or other factor that affect your health . The two drugs have some of the same precautions , but they also have different I . Some of these precautions are mentioned below .
If any of the following medical conditions or other health factors are relevant to you , blab with your doctor before using Nucala or Dupixent .
Switching between Nucala and Dupixent
Switching between Nucala and Dupixent might be potential .
If you ’d like to bonk more about switch between Nucala and Dupixent , talk with your doctor . They can give you extra details and help determine the good path of natural action for your personal situation . Even if two drug treat the same status or are in the same drug class , your consistency can still answer differently .
It ’s important that you do not stop , start , or switch any of your drug treatments without your Doctor of the Church ’s good word .
Disclaimer : Medical News Today has made every effort to make certain that all information is factually right , comprehensive , and up to date . However , this article should not be used as a fill-in for the cognition and expertise of a commissioned health care professional . You should always consult your doc or another health care professional before taking any medicament . The drug data check herein is subject to change and is not intended to cover all possible function , directions , precautions , warnings , drug interaction , sensitized reactions , or inauspicious effects . The absence seizure of warnings or other entropy for a given drug does not point that the drug or drug compounding is safe , effective , or appropriate for all patients or all specific use .
