Prolia ( denosumab ) is a steel - name injection that ’s prescribe for osteoporosis and other U.S.A. . Prolia has interactions with some other drug . lesson include corticosteroids and calcimimetics .
Prolia is prescribed for the following uses in adults :
Aninteractionoccurs when one substance causes another substance to have a unlike effect than expected .
By study about possibleProliainteractions , you could work with your doctor to ensureProliawill be dependable and effective for you to take . For additional information aboutProlia , including point about its uses , see thisProliaoverview clause .
- Sex and genderexist on spectrum . Use of the terms “ male ” and “ distaff ” in this clause refers to gender assigned at birth .
Prolia interactions with other medications
Before you startle discussion with Prolia , tell your doctor and druggist which prescription medicine , over - the - tabulator , and other medicament you take . By sharing this information with them , you may help preclude potential interaction . ( To con whether Prolia interacts with supplements , herbs , or vitamins , see the “ Prolia and other interactions ” section . )
If you have questions about drug interaction that may touch on you , call for your doctor or pill roller .
Here ’s a table of drug that can interact with Prolia . Keep in brain that this mesa does n’t include all drugs that may interact with Prolia . Some of these interactions are name in point in “ Drug interactions in depth . ”
When to avoid Prolia
In some case , factors or conditions could keep your doctor from prescribing Prolia due to the endangerment of harm . These are known as contraindication . The contraindications of Prolia include :
Having low blood calcium
doctor typically wo n’t order Prolia if you have low blood atomic number 20 ( hypocalcemia ) . Prolia can cause hypocalcemia as a side consequence , and this side effect can be life threatening in extreme cases . If you already have hypocalcaemia , handling with Prolia could exacerbate it .
As a resultant , your doctor will dictate discourse for hypocalcaemia before prescribing Prolia to you . Or they can recommend a dissimilar treatment for your condition besides Prolia .
Are pregnant or may become pregnant
Doctors typically wo n’t dictate Prolia during pregnancy . They ’re also improbable to prescribe the drug for this use if you ’re able-bodied to become meaning and are not using effectivebirth controller .
This is because Prolia may not be secure to take during maternity .
For intervention ofosteoporosisor low bone mass during pregnancy , your Doctor of the Church can urge a dissimilar treatment that ’s secure for use in gestation . If you ’re able-bodied to become fraught , your Dr. can advise you on birthing control option to use while postulate Prolia for your condition .
Having had an allergic reaction to Prolia or any of its ingredients
If you have had anallergic reactionto Prolia or any of its ingredients , your doctor will probably not order Prolia . Taking the drug could get another supersensitive reaction . you may ask them about other discourse that may be dear choices for you .
Note : Before you start treatment with Prolia , it ’s important to tell your doctor if these contraindications apply to you . They can determine whether to order Prolia .
Prolia interaction with alcohol
There are n’t any know interactions between Prolia andalcohol . However , your medico may apprise you to avoid or limit alcohol consumption during Prolia treatment .
This is because drinking alcohol may increase your peril of off-white faulting , especially if you have osteoporosis or another condition causing low bone mass .
If you have questions about drink alcohol during Prolia intervention , talk with your medico .
Drug interactions in depth
Here ’s a closer feeling at certain drug fundamental interaction of Prolia .
Corticosteroids
Prolia can interact withcorticosteroids . Corticosteroid medications are prescribed to treat many different conditions , admit skin conditions such aseczemaandpsoriasis , as well as seditious bowel disease , asthma , andmultiple sclerosis ( MS ) .
fundamental interaction termination : Taking Prolia and corticosteroids together can increase the risk ofosteonecrosis of the jaw ( ONJ)as a side effect of Prolia or adrenal cortical steroid .
fundamental interaction explained : Both Prolia and corticosteroids can cause ONJ when used on their own . engage these medications together further increase the risk of this side consequence .
Examples of corticosteroid drugs : Here are some corticosteroid that may interact with Prolia :
Steps you or your doctor may take : Your physician may decide to avoid prescribing Prolia and corticosteroid together to avoid this interaction . If your doctor order Prolia and a corticosteroid together to you , they ’ll likely have you watch close for any symptoms of ONJ . You should immediately notify your Dr. if you remark symptom such as pain in your mouth , worry chew , and swelling in your gums or soft tissue paper inside your mouth .
Calcimimetics
Prolia can interact with calcimimetics , which are prescribe to treathyperparathyroidism , admit hyperparathyroidism related tochronic kidney disease .
Interaction resolution : take Prolia and a calcimimetic together can increase the risk of low rakehell calcium ( hypocalcaemia ) as a side effect of Prolia or calcimimetics .
Interaction explained : Taken on their own , Prolia and calcimimetics can cause hypocalcaemia as a side effect . If these medications are direct together , the risk of this side effect increases .
Examples of calcimimetics drugs : Here are some calcimimetics that may interact with Prolia :
step you or your doctor may take : Due to this interaction , your doctor may prefer to avoid prescribing Prolia and a calcimimetic medication together . Or , if they prescribe this combining to you , they ’ll probably closely supervise your line of descent calcium story . They ’ll also likely commend you take a vitamin D and Ca supplement throughout treatment with Prolia .
Immunosuppressants
Prolia can interact withimmunosuppressantmedications . immunosuppressant are medications that lowerthe activity of yourimmune system . Many medications are considered immunosuppressants . They have a variety of unlike uses , include preventing electronic organ rejection after an organ organ transplant and treating conditions such as certain cancers and autoimmune conditions , such aslupus .
Interaction termination : Taking Prolia and an immunosuppressant together can increase the risk of contagion as a side effect of Prolia or immunosuppressants .
Interaction explained : Treatment with Prolia or an immunosuppressive on its own raise your danger of infection as a side effect . have these medications together further raises your risk of contagion as a side issue .
Examples of immunosuppressant drug : Here are some immunosuppressant drug that may interact with Prolia :
Steps you or your Dr. may take : If your doctor order Prolia and an immunosuppressant for you to take , they may monitor you closely for contagion throughout treatment . Be sure to meet your doctor right away if you think you have symptom of an infection , as they ’ll in all likelihood require to regale it the right way off .
Your doctor may also make up one’s mind the jeopardy outbalance the benefit and that you should not take Prolia with an immune suppressant drug . In this case , your doctor can advocate an alternative intervention besides Prolia or the immune suppressant drug for your stipulation .
Prolia and other interactions
Prolia may have other interactions , such as with supplements , food , vaccines , or even lab test . You ’ll find details below . Keep in mind that the following information does not include all other potential fundamental interaction with Prolia .
Prolia interactions with supplements
Before you start handling with Prolia , tell your doctor and pill roller whichsupplements , herbs , andvitaminsyou take . By sharing this information with them , you may assist prevent possible interactions .
There are no specificreportsof herbs interacting with Prolia . However , that does n’t mean herbal interaction wo n’t occur or be recognise in the future . Because of this , it ’s important to watch with your MD or apothecary before taking any of these products during Prolia discussion .
There are no specificreportsof vitamins interact with Prolia . However , that does n’t intend vitamin interaction wo n’t go on or be recognized in the futurity . Because of this , you should talk with your doctor or pharmacist before taking any vitamin merchandise with Prolia .
Prolia interactions with food
There are noreportsof food interaction with Prolia . If you ’d like to read more about eat sure foods during discussion with Prolia , verbalize with your doctor .
Prolia interactions with vaccines
Prolia may interact with resilient vaccines . A live vaccine incorporate live but weakened pieces of the computer virus or bacterium it ’s meant to defend against . When your immune system is healthy , bouncy vaccines ordinarily wo n’t cause infection .
But Prolia treatment may weaken your immune system . So if you get a alive vaccine , your immune system may not be able to press the virus or bacterium . This may induce you to become sick or germinate symptoms of the sickness the vaccine is meant to prevent .
Examples of live vaccinum to head off during Prolia handling let in :
Before starting Prolia , sing with your doctor or pharmacist about any vaccines you may need .
Prolia interactions with lab tests
Prolia may interfere with the termination of the tuberculinpurified protein differential coefficient ( PPD ) skin test . Specifically , Prolia treatment may have a fictitious - negative result for this trial . A untrue - negatively charged for the tuberculin PPD cutis test means the test shows you do n’t havetuberculosis ( TB)but an transmission is actually present .
Due to this , your doctor may order a different test if you need a trial to check for TB .
For additional information , talk with your Doctor of the Church or pharmacist .
Cannabis(often called marijuana ) and cannabis products , such as cannabidiol ( CBD ) , have not been specificallyreportedto interact with Prolia . However , as with any drug or supplement , talk with your MD before using cannabis in combination with Prolia . The impact of cannabis may regard how well you stick to your Prolia discussion plan . Note : Cannabis is illegal at a federal level but is legal in many states to vary degrees .
Prolia and health-related interactions
Certain aesculapian conditions and other factors may increase the jeopardy of interaction with Prolia . Before you take this drug , be sure to blab out with your Dr. about your health story . Prolia may not be the good discourse choice if you have certain medical condition or other factors affecting your wellness .
wellness conditions or factor that might interact with Prolia let in :
FAQs about Prolia and interactions
Here are some frequently asked motion about Prolia and possible interactions .
Can you take Prolia while on antibiotics?
Yes , it ’s usually safe to receive Prolia while takingantibiotics . Antibiotics and Prolia aren’treportedto interact .
handling with Prolia can bring up your risk ofinfection , include infections by bacteria . In this case , your medico may prescribe an antibiotic to regale your transmission . Be sure to portion out your medication list with your doctor , as antibiotic can interact with other medicine . There are legion different antibiotics , and they have different fundamental interaction . But they ’re not wait to interact with Prolia .
Is there an interaction between Prolia and statins?
No , it ’s not think so . There aren’treportsof interactions between Prolia and statins .
Statinsare medications order to take down cholesterin as well as sealed wellness endangerment in sure people . lipid-lowering medicine can interact with other medications , and these interactions can take issue based on the specific statin . But Prolia is n’t expected to interact with lipid-lowering medicine .
Your Dr. or pharmacist can advise you on whether other medications you take interact with statins .
Preventing interactions
you’re able to take sure steps to help prevent interactions with Prolia . Your doctor and pharmacist are key resources , so reach out to them before starting treatment . For lesson , you should contrive to do the following :
It ’s also important to read the Prolia recording label and otherpaperworkthat may come with the drug . The label may have colored paster that observe an interaction . And the paperwork , sometimes call up the medicinal drug guide or patient package cut-in , may contain details about interactions .
If Prolia does n’t come in with paperwork , you could ask your pharmacist to impress a copy . If you involve aid reading or see this entropy , ask your doc or pharmacist .
you’re able to also serve keep interactions with Prolia by using it precisely as your medico prescribes .
Disclaimer : Medical News Today has made every effort to make certain that all info is factually right , comprehensive , and up to date . However , this article should not be used as a substitute for the cognition and expertise of a licensed healthcare professional . You should always consult your Dr. or another health care professional before taking any medication . The drug information contained herein is subject to variety and is not specify to track all possible usage , directions , precaution , warnings , drug fundamental interaction , sensitised reaction , or adverse effects . The absence seizure of warnings or other data for a given drug does not betoken that the drug or drug combining is safe , effective , or appropriate for all patients or all specific uses .