Rapamune ( sirolimus ) is a brand - name drug that ’s prescribed to avail prevent kidney transplant rejection and to treat a rare lung shape . It ’s used in adults and sealed children . As with other drugs , Rapamune can cause side effect .
Rapamune hasboxed admonition . A boxed monition is the most serious warning from the Food and Drug Administration ( FDA ) . For details , see the “ boxed-in warnings for Rapamune ” section .
More common side effects of Rapamune
Rapamune can cause certain side impression , some of which are more coarse than others . These side upshot may be irregular , lasting a few days to hebdomad . However , if the side outcome last longer than that , bother you , or become severe , be certain to talk with your doctor or pharmacist .
These are just a few of the more common side result report by the great unwashed who took Rapamune inclinical trial :
Mild side effects of Rapamune
modest side effects can pass with Rapamune use . This list does n’t let in all possible mild side effects of the drug . For more information , you may consult to Rapamune’sprescribing information .
meek side effects that have been account with Rapamune include :
These side effects may be irregular , lasting a few sidereal day to calendar week . However , if the side consequence last longer than that , discommode you , or become grievous , be certain to talk with your doctor or pharmacist .
Note : After the Food and Drug Administration ( FDA ) approves a drug , it tracks and review side effects of the medication . If you develop a side effect while taking Rapamune and want to tell the FDA about it , visitMedWatch .
Serious side effects of Rapamune
Rapamune may cause serious side effects . The list below may not include all possible serious side effects of the drug . For more information , you’re able to touch to Rapamune’sprescribing information .
If you develop serious side essence while taking Rapamune , call your Dr. right away . If the side effects seem life-time imperil or you think you ’re having a aesculapian pinch , immediately call 911 or your local emergency number .
Serious side effects that have been account and their symptoms include :
- For detail about these peril , see the “ Boxed warnings for Rapamune ” section.† For more selective information about this side effect , see the“Side effect specifics”section .
For some multitude , Rapamune can have anallergic reaction . In worldwide , symptom of supersensitized response can be mild or serious .
shipway to manage
For balmy hypersensitised reaction symptom , such as a balmy rash , call your doctor mightily off . They may urge discussion to assist manage your symptom . They ’ll also let you know whether you should keep taking the medicine .
For life-threatening allergic response symptom , such as swelling or fuss breathing , call 911 or your local emergency number flop out . These symptoms need prompt medical guardianship because they can become living menace . If you ’ve had a serious allergic reaction to Rapamune , your doctor may recommend taking a different medication or else .
Boxed warnings for Rapamune
Rapamune hasboxed warningsabout the jeopardy ofinfectionandcancerand peril withliveror lung transplants . A boxed word of advice is the most serious warning from the Food and Drug Administration ( FDA ) . Be certain to talk with your doctor if you questions or concerns about these monition .
Risk of infection and cancer
Rapapmune is animmunosuppressant . This means it canweaken your immune system of rules . A rickety resistant system can avail foreclose your body from rejecting akidney transplant . But it can also increase the risk of let contagion and develop genus Cancer .
Symptoms of PML and serious infection let in :
Taking Rapamune can also increase the risk of developing cancers . Inclinical trials , lymphomaandskin cancerswere common . Symptoms of cancer may admit :
If you have symptom of PML or another serious contagion , get aesculapian precaution the right way away by calling 911 or your local emergency turn .
you may help oneself protect yourself from infections by taking these stairs :
To help protect yourself from tegument cancer , you’re able to cover disclose skin in the sunshine and have on dailysunscreen . Avoidtanning bedsandsmoking .
If you break a serious infection or Cancer the Crab while taking Rapamune , your MD may conform yourRapamune dosageor change your intervention plan to help lower your risk . For transmission like BK virus or PML , your doctor may thin the strength of any other immunosupressant drug you may be taking .
For cancers , your doctor may hint regular checkups , monitoring , or further tests likebiopsiesto guide handling .
If you have fear , talk with your doctor about how to monitor for these conditions during treatment .
Risk with liver or lung transplants
Rapamune may not be safe or effective in hoi polloi with liver or lung transplants . Inclinical trial , there was an increase danger of serious complications , including transplant failure and last , when taken during these types of transplant .
Due to the risk of increased complications and demise , Doctor of the Church typically do n’t dictate Rapamune for people who will have liver or lung transplants .
mouth with your MD if you have questions or concerns about this admonition .
Side effect specifics
Learn more about some of the side effects that Rapamune may cause . To regain out how often side issue occurred in clinical trials , see theprescribing informationfor Rapamune .
Decline in kidney function
Rapamune may affect kidney function . Inclinical trials , multitude who take Rapamune withcyclosporine(Gengraf , Neoral , Sandimmune ) recollective term had a decline in kidney procedure . Dr. measured this with a blood test that measuresserum creatinine .
Kidney subroutine was also affected in people who were taking a calcineurin inhibitor drug , such astacrolimus , and switched to Rapamune . Doctors measured this by checking the amount ofprotein in their urine . This modification in kidney function was vernacular in clinical test of Rapamune .
symptom of kidney function descent include :
Due to the endangerment of declining kidney map , doctors typically go over kidney social function during Rapamune discussion . This may let in check serum creatinine and water protein level on a even foundation .
If you also take cyclosporine , tattle with your doctor about the possible effect on your kidney function . If you develop symptoms of kidney problems , tell your doctor properly away .
Swelling
Rapamune may make fluid to establish up in your physical structure , such as in your belly , lung , or around your heart , which can make ventilation or moving harder . It may also slow down combat injury healing , especially if you haveoverweight .
Rapamune can stimulate several types of swelling , some of which were very common inclinical trials . The following type of swelling were report :
Peripheral edema was the most rough-cut side impression reported in clinical trials of Rapamune .
Get aesculapian care right aside if you have brusqueness of breath , trouble breathing that feels serious , or excrescence of your oral fissure or pharynx . you could call 911 or your local emergency number .
distinguish your doctor if you have swell in any organic structure part or mild hassle breathing . They may recommend treatment to help reduce the bump .
FAQ about the side effects of Rapamune
Rapamune may stimulate several side effects . Here are some ofttimes ask doubt about the drug ’s side effects and their result .
Does Rapamune cause long-term side effects?
Yes , it ’s potential . Some side effect of Rapamune can continue as long as you take the drug . instance include a weakened immune system that increase the danger of contagion and Cancer the Crab . Fertility problem and high-pitched cholesterol and triglycerides may also continue for as long as you take the drug .
If you have side effects that are n’t go away , tell your Doctor of the Church . They may be able-bodied to suggest ways to manage them . Also , speak with your doctor if you ’re concerned about taking Rapamune foresightful term .
Does low dose Rapamune cause side effects?
Yes , Rapamune can have side gist at low doses . Side effects are generally dose link with Rapamune . This intend they ’ll be more likely to happen with high doses , but they can still happen with low-down doses . Inclinical trial , the side force were mostly the same for low dose Rapamune as they were at higher doses .
speak with your doctor if you ’re have side effects that are nettlesome or are concerning . They may be capable to suggest ways to manage them .
How do the side effects of Rapamune and tacrolimus compare?
Rapamune and tacrolimus partake in some side effects and have different ones . They ’re both immunosuppressant drugs . But they belong to different drug class . Rapamune belongs to a drug grade called mammalian fair game of rapamycin ( mTOR ) inhibitor . Tacrolimus is a calcineurin inhibitor .
Both drug can increase the risk of infection of infection or developing Crab . * They can also cause problem with kidney function and swelling.†
Each drug also has side effects , both mild and serious , that the other does n’t . To learn more about how these two drugs compare , blab with your doctor .
- For details about these side effects , see the“Boxed warning for Rapamune”section.†For more information about these side effects , see the“Side gist specifics”section .
Precautions for Rapamune
Below is of import information you should consider before adopt Rapamune .
Other precautions
Before taking Rapamune , discuss your health story with your Dr. . Rapamune may not be right for you if you have certain medical weather condition or other factors touch your health . Be indisputable to speak with your MD if any of the following apply to you :
Disclaimer : Medical News Today has made every attempt to make sealed that all information is factually correct , comprehensive , and up to date . However , this clause should not be used as a fill-in for the knowledge and expertise of a licenced health care professional . You should always confabulate your doctor or another health care professional before taking any medication . The drug information contained herein is open to change and is not intended to cover all potential usance , directions , precautions , warnings , drug interactions , sensitised reaction , or adverse effects . The absence of warnings or other information for a gift drug does not indicate that the drug or drug combination is safe , effective , or appropriate for all patients or all specific uses .
