As with other drug , clopidogrel can cause side effects , such as bruising and haemorrhage . If you are not able to tolerate side effects from clopidogrel , talk with your doctor or pharmacist .
Clopidogrel is agenericdrug that ’s prescribe to help preventheart attackandstrokein adult with :
Clopidogrel comes as an unwritten tablet . Clopidogrel is also usable as the brand - name drug Plavix .
say on to find out about potential unwashed , soft , and serious side effects of clopidogrel . For more entropy about clopidogrel , admit particular about its uses , see thisclopidogreloverview .
Clopidogrel has aboxed monition . A boxed admonition is the most serious monition from the Food and Drug Administration ( FDA ) . For details , see the “ Clopidogrel : Boxed warning ” section .
Clopidogrel: More common side effects
Clopidogrel can cause sure side effects , some of which are more coarse than others . These side effects may be temporary , lasting a few day to weeks . However , if the side essence persist , trouble oneself you , or become severe , be sure to speak with your Doctor of the Church or pharmacist .
These are just a few of the more common side effects report by masses who deal clopidogrel inclinical trial run :
Clopidogrel: Mild side effects
Mild side effects can occur with clopidogrel use . This lean does not include all potential soft side effects of the drug . For more information , you’re able to name to the drug’sprescribing information .
Mild side effects that have been cover with clopidogrel include :
These side effects may be temporary , lasting a few days to week . However , if the side effect continue , devil you , or become severe , be certain to peach with your doctor or pharmacist .
For more info about some of these side effects , see the “ Clopidogrel : Side effect specific ” surgical incision .
Note : After the Food and Drug Administration ( FDA ) okay a drug , it tracks and brush up side effect of the medication . Sharing your experience helps make medications safe for everyone by giving doctors and researchers more information about how the drug works in real life . If you evolve a side effect while taking clopidogrel and want to separate the FDA about it , visitMedWatch .
Clopidogrel: Serious side effects
Clopidogrel may make serious side core . The following list may not include all possible serious side effects of the drug . For more information , you could refer to theprescribing informationfor clopidogrel .
If you develop serious side effects while ask clopidogrel , call your doctor decent forth . If the side effect seem spirit threaten or you think you ’re suffer a aesculapian emergency , forthwith call 911 or your local emergency identification number .
Serious side personal effects that have been reported with clopidogrel include :
For more entropy about these side burden , see the “ Clopidogrel : Side outcome specifics ” surgical incision .
For some people , clopidogrel can cause anallergic reaction . This side essence was n’t report in the drug’sstudies , but it has been reported since the drug was approved .
In general , symptoms of supersensitized reaction can be mild or serious .
Ways to manage
For mild allergic response symptoms , such as a mild roseola , call your doctor right away . They may recommend discussion to aid manage your symptoms . They ’ll also let you get it on whether you should keep take the medicinal drug .
For severe supersensitive reaction symptom , such as bulge or problem ventilation , call 911 or your local pinch number decent away . These symptoms need contiguous medical care because they can become life jeopardise . If you ’ve had a serious allergic reaction to clopidogrel unwritten tablet , your doc may recommend taking a different medication instead .
Clopidogrel: Boxed warning
Clopidogrel has aboxed warning . A boxed warning is the most serious warning from the FDA .
Reduced effect in people with certain drug metabolism problems
For clopidogrel to mold for you , your body first has tometabolize(break down ) the drug into its active form . Anenzymein your body call cytochrome p450 2C19 ( CYP2C19 ) is responsible for this . If CYP2C19 does n’t work well , clopidogrel may not be effective for you . This have in mind it may not work to assist foreclose heart attack and stroke .
CYP2C19 may not work well if you have certain genetic factor that cause you to have a less active version of this enzyme . ( This is forebode being a CYP2C19 poor metabolizer . ) Your doctor may order certaingenetic testsbefore prescribing clopidogrel to ensure the drug is correct for you .
CYP2C19 may also not mould well if you take sure medication , especiallyomeprazole(Prilosec ) or esomeprazole ( Nexium ) . These medication slow down the action of CYP2C19 . Your doctor likely will not order clopidogrel with these medication .
If either of these cistron apply to you , talk with your MD before taking clopidogrel . Your physician may dictate a medicine other than clopidogrel to help forestall affection onrush and stroke .
While taking clopidogrel , you should not take over - the - rejoinder medication that carry Prilosec ( Prilosec OTC ) or esomeprazole ( Nexium 24HR ) .
If you have questions about this monition , let the cat out of the bag with your doctor or pill roller .
Clopidogrel: Side effect specifics
Learn more about some of the side gist that clopidogrel may cause . To feel out how often side outcome happen in clinical trials , see theprescribing informationfor clopidogrel .
Bleeding
Clopidogrel is ablood thinnerthat aid prevent heart attack and stroke by making it harder for your blood to formclots . Because of this , the medication can get up your risk ofbleeding . Bleeding was the most vulgar side result reported instudiesof clopidogrel . Minor hemorrhage was common , while major bleeding occur rarely . Major bleeding can be life story threatening .
example of minor hemorrhage can let in :
Examples of major bleeding includeinternal hemorrhage , such as in your digestive system , urinary tract , lungs , orbrain . symptom of major haemorrhage alter look on the location of bleed but can admit :
Factors that can increase the risk of bleeding when taking this drug let in feature operation and ingest sealed other drugs . Examples of medicine that may increase this risk include :
To assist prevent haemorrhage while taking clopidogrel , take supernumerary care when using sharp tools or doing activities that could extend to injury . If cycling , be sure to wear a helmet . Always check with your doctor or pharmacist before take other drugs with clopidogrel .
If you have an upcoming surgical operation or dental procedure , be indisputable to talk with your medico at least 5 twenty-four hours beforehand . In some cases , your MD may advocate temporarily stopping clopidogrel before surgery to shrink your risk of phlebotomize .
While taking clopidogrel , see your Dr. mightily aside if you have symptom of major bleeding . Also , see your Doctor of the Church justly away if you have a head teacher injury . They ’ll likely execute trial run to ascertain for major haemorrhage . If you have a major bleed , your doctor may temporarily barricade your clopidogrel handling .
Note that you should not stop taking clopidogrel unless your doctor recommends this . Stopping clopidogrel can rear your risk of heart flack and stroke .
If you have questions about the peril of bleed with clopidogrel , blab with your doctor or pharmacist .
Thrombotic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura ( TTP)can come about with clopidogrel . This side consequence was n’t report instudiesof clopidogrel but has been account since the drug became useable . TTP is a uncommon but serious disorderliness in which blood clots manakin in little blood watercraft in your consistence .
TTP may cause symptoms such as :
If you have symptom of TTP that pass without an obvious cause , see your doctor right away . They ’ll likely order blood tests to delay for TTP . If you have this term , you ’ll likely need treatment in a infirmary . Your MD will likely halt your clopidogrel treatment .
If you have question about the risk of TTP with clopidogrel , talk with your doctor or pharmacist .
Clopidogrel: FAQ about side effects
Here are answer to some frequently asked enquiry about clopidogrel ’s possible side effect .
Can clopidogrel cause side effects in older adults?
Clopidogrel can cause interchangeable side effects in old ( age over 65 years ) and other adults who take the medicinal drug . The most common side effect is an increased peril of haemorrhage . To read more about this side effect , see the “ Clopidogrel : Side effect particular ” incision .
Doctors typically prescribe the same dosage of clopidogrel for old grownup and other adult .
If you have question about the safety of clopidogrel given your eld , lecture with your doctor or druggist .
Does takingatorvastatin with clopidogrel cause side effects?
No , that ’s not likely . Atorvastatin ( Lipitor ) and clopidogrel are not know to interact . And they do n’t get similar side effects . It ’s generally considered safe to take these medications together .
Atorvastatin is order to lowerhigh cholesterol level , while clopidogrel is prescribed to help prevent stock coagulum . Doctors usually dictate atorvastatin with clopidogrel to aid preclude heart onrush and stroke . ( Sometypes of blood clotscan cause heart attack or stroke . )
If you have questions about taking atorvastatin with clopidogrel , talk with your doctor or druggist .
Does clopidogrel cause long-term side effects?
It ’s unbelievable . Long - term side effects were n’t reported instudiesof clopidogrel . Long - terminal figure use of clopidogrel is n’t known to raise the hazard of side effect from the drug .
recollective - condition side personal effects include those that may start at any time you ’re taking a drug , even if you ’ve choose it for a long time . It also include side effects that may not go off , even after you give up taking the drug .
If you ’re interested about potential long - condition side consequence from clopidogrel , talk with your Dr. or chemist .
Clopidogrel: Precautions
study the following important information before taking clopidogrel . Clopidogrel has aboxed warning . A boxed admonition is the most serious admonition from the Food and Drug Administration ( FDA ) . For detail , see the ” Clopidogrel : box warning ” segment .
Other precautions
Before taking clopidogrel , discuss your health story with your doctor . Clopidogrel may not be right for you if you have certain aesculapian conditions or other factors dissemble your health . Be sure to blab out with your doctor if any of the following employ to you :
For information about clopidogrel and gestation or breastfeeding , see thisclopidogrel reproductive healtharticle .
Disclaimer : Medical News Today has made every effort to make certain that all information is factually correct , comprehensive , and up to date . However , this clause should not be used as a substitute for the knowledge and expertise of a commissioned health care professional . You should always confer with your doctor or another healthcare professional before taking any medicinal drug . The drug info control herein is subject to change and is not intended to cover all potential uses , directions , precaution , warnings , drug interaction , allergic reactions , or adverse effect . The absence of warnings or other info for a given drug does not bespeak that the drug or drug combination is good , effective , or appropriate for all patients or all specific use .
