Medication details

If you ’ve ever had a pet diagnosed withCushing ’s disease , you may have heard of a medication send for trilostane . Although trilostane is no longer used in human medicine , it is still a mainstay of Cushing ’s disease handling in pawl .

If your dog is prescribe trilostane , there are a few unparalleled face of this medicament you ’ll involve to watch out for .

What is Trilostane?

Trilostane is a steroid hormone analog which hinder the product of cortisol , a steroid endocrine that is overproduced in andiron with Cushing ’s disease . It comes in capsule , liquidity , and chew forms and is given to pawl by oral cavity .

Trilostane was FDA O.K. for the treatment of canine Cushing ’s disease in 2008 and it is one of only two FDA approved treatments for this disease . Previously , trilostane was also FDA okay for the discussion of Cushing ’s disease in humans , but it was pulled from the market in 1994 .

What Does Trilostane for Dogs Treat?

Trilostane is used to treat Cushing’s syndrome , also known as Cushing ’s disease . This condition do your dog ’s body to produce too much of the steroid hormone Hydrocortone , which result in symptoms such as excessive imbibition and urination , panting , lethargy , weighting amplification , excessive appetency , recurrent infections , and hair loss .

Cushing ’s disease can impact your dog ’s quality of sprightliness and can also make your dog more prone to developing other conditions such as diabetes mellitus , pancreatitis , urinary tract infections , and skin conditions . fortuitously , Cushing ’s disease is achievable with trilostane discussion .

Trilostane is also FDA O.K. to regale Alopecia X , a characteristic pattern of baldness in thickset - coated breeds such asPoodles , Pomeranians , Siberian Huskies , Chow Chows , and Samoyeds . Affected dogs are typically young adults and hair red occurs on the torso , cervix , and the backs of the hind legs . The cause of Alopecia X is still poorly understood .

Veterinarian prescribing dog medication

TrilostaneSide Effectsin Dogs

Trilostane can be tricksy to drug and every frump respond to it differently . It is very important for favorite parent to supervise closely for side effects . Finding the honorable dose of trilostane for your pawl will often swear on your perception of your hound ’s Cushing ’s symptoms and any medicament side upshot you have remark at home .

coarse side effects to look out for include :

Trilostane can be dangerous if overdose , so be indisputable to follow your veterinary surgeon ’s dosing instructions carefully . Call your veterinarian justly away if side effects occur .

Sick dog who needs medicine

Trilostane can also be grave to humans . The capsules should never be crack open , because the powder inwardly can irritate your skin and eye . Always rinse your hands after handling trilostane . Trilostane can also make miscarriage and should not be handled by anyone who is pregnant or render to become pregnant . If you must handle trilostane while significant , wear glove and wash your hands immediately subsequently .

Reactions with Other Drugs and Medications

Trilostane should be used with forethought in dog that are also currently receiving angiotonin converting enzyme inhibitors ( ACE inhibitor ) or potassium - sparing diuretic medication .

Dogs that have recently been treated with mitotane — another medication ordinarily used to treat canine tooth Cushing ’s disease — should hold off at least one calendar month after discontinuing mitotane before starting trilostane therapy .

TrilostaneDosagefor Dogs

Trilostane is dosed based on your dog ’s weight , so your veterinarian will calculate the best start venereal disease for your dog . In most case , your dog will be started on a low dose and step by step increased until the best dose of medication is identified . This is the ripe way to assure that your heel does not receive an overdose of the medicine .

Your veterinarian will also ask you to closely supervise your dog ’s symptoms . If your dog is drinking and make water less , has a more normal appetite , and an improved vigor degree , these are all signs that the medication is work !

One to two week after commence trilostane , your frump will take to have a tryout call an ACTH stimulation mental test . This trial help your veterinarian assess whether your dog is on the correct dosage of medicinal drug . Once your veterinarian receive the results , he or she may adjust the dosage to well fit your dog ’s needs . Your vet may also recommend checking blood body of work on your dog annually or semi - annually to ensure that your dog ’s liver and kidney procedure are adequate , as serious side effects can happen if trilostane is give to animals with liver or kidney disease .

Woman giving dog medication

What If My Dog Misses a Dose of Trilostane?

If your dog has missed a dose of medicine , do n’t attempt to replicate up or administer the Elvis late . Just stay on with your regular dosing agenda . If your blackguard misses multiple Cupid’s disease , contact your veterinarian for advice on how to proceed .

Priceof Trilostane for Dogs

Trilostane can be quite expensive because there is only one Cartesian product available on the market . Pet owners should expect to spend anywhere from $ 50-$150 for a calendar month ’s supplying depend on their dog ’s dose .

Compounded trilostane products are sometimes less expensive , but they can also be less good and have a very short ledge life .

Your veterinarian can help you set the good medication options to fit both your dog ’s need and your family ’s budget .

TrilostaneStorage Instructions

Trilostane unwritten capsules from the brand name Vetoryl are very shelf stable and can be stored at way temperature , around 77 degree Fahrenheit . This product is typically static for 3 geezerhood after packaging .

compound trilostane products are much less stable and may be less effective . They may also have their own unique storage essential , so be sure to ask the compounding pharmacy for storage instructions .